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KMID : 0043319990220040410
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Archives of Pharmacal Research
1999 Volume.22 No. 4 p.410 ~ p.413
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Inducible Nitric Oxide Synthase Inhibitor form Mela azedarach var. Japonica
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Kwon Hak-Cheol
Lee Byeong-Gon
Kim Seung-Hee
Jung Chil-Mann
Hong Sung-Youl
Han Jeung-Whan
Lee Hyang-Woo
Zee Ok-Pyo
Lee Kang-Ro
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Abstract
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In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two -carboline (2) have been isolated form the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 to 2 showed marked inhibitory activity of iNOS on LPS-and interferon--stimulated RAW 264.7 cells.
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KEYWORD
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Melia azedarach var. japonica 4-Methoxy-1-vinyl-carboline, 4, 8-Dimethoxy-1-vinyl--carboline, Inducible nitric oxide synthase
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